The never-ending quest for eternal youth and beauty is the bread and butter of the beauty industry, and it looks like NewYew is the company that has hit the winning jackpot. Their secret weapon (literally) is scientist Lyle Fontanelle, who has developed a lotion that can cause a body to create more collagen, good for burn victims, and Lyle hopes, eventually… cancer patients. But the corporate bigwigs want to push through with the testing and manufacturing against Lyle’s better judgment. An accidental lapse in safety protocols cause the lotion to be tainted. During the test run, most of the subjects start turning into Lyle, and one man starts turning into his assistant (a woman). That doesn’t end pretty. The tainted lotion overwrites one’s DNA, and the quick knowledge spread of the lotion’s capabilities start spiraling the drain, leading all to want an Extreme Makeover by Dan Wells.